ACTA1 and Hepatic fibrosis: In the study, we confirmed that Sal B could promote the reversion of established liver fibrosis in DMN induced model, demonstrated by the decreased levels of α-SMA, Col-I, and hydroxyproline in Sal B treatment group, and Sal B had a similar effect on liver fibrosis as perindopril, which can reduce Ang-II production and liver or kidney fibrosis.