MAP2K5 and Cirrhosis: Taken together, these findings indicate that both the JAK-STAT3 and the MEK5-ERK5 pathways related genes were overexpressed by IL-6 expression in response to CCl4-induced cirrhosis-associated cardiac hypertrophy (Figure 6), which confirms the importance of the two pathways and also demonstrates that their overexpression may be reversed by OGE or silymarin treatment thus lowering liver cirrhosis and reducing the chance of cardiac hypertrophy.