Our results showed that T-bet, Hlx, Runx3, and IFN-γ expression in transcription and protein levels were significantly lower in gastric carcinoma group than that in control group, but the results of GATA3 and IL-4 were opposite, which could demonstrate that the decreasing cell-mediated immune ability from gastric cancer state and a typical Th2 cells drifting had happened in gastric carcinoma. Here, RUNX3 is linked to gastric carcinoma.