The clinical, immunologic, and molecular features of the patients are listed in Table 1 and were consisted with a phenotype of classical SCID with maternal-fetal transfusion (Pt1, Pt2), SCID-Omenn (Pt3, Pt4) or the combined immunodeficiency (CID) MHC II deficiency (Pt5, Pt6). Here, ZNF135 is linked to severe combined immunodeficiency.