Nonetheless, in the described scenario, our data plus literature data are well grounded and provide evidence that the BDKRB2 gene may constitute not only a link between biomechanical transduction and diabetes condition, but may also be a fundamental gateway for both epidemiological and mechanistic studies involving diabetes, hypertension, and renin-angiotensin system hyperactivity. Here, BDKRB2 is linked to hypertensive disorder.