Recently, the TAM family of RTKs has been reported to regulate various biological processes.5 This family consists of Tyro3 and Mer as well as Axl.6 Axl has already been reported to be overexpressed in several human cancers.7–11 Its natural ligand, Gas6, binds Axl with three- to tenfold higher affinity than Mer and causes Axl phosphorylation, which results in activation of various downstream pathways.12,13 Thus, Axl/Gas6 signaling contributes to a variety of oncogenic mechanisms.14,15. This evidence concerns the gene GAS6 and cancer.