Interestingly, when instead of recombinant CD1d proteins, iNKT cells and SKBR-3 tumor cells were co-incubated with αGC-pulsed C1R-CD1d cells or moDCs, less than 20 % of SKBR3 cells became Annexin V positive (Fig. 4a), although the percentages of CD107a, IFNγ and TNFα-positive iNKT cells (Fig. 4b, c) were similar after incubation with the tumor-targeted αGC/sCD1d-anti-HER2 protein or with αGC/C1R-CD1d cells. Here, ERBB2 is linked to neoplasm.