Second, the targeting of CD1d molecules to cancer cells by their fusion to an antitumor scFv fragment efficiently redirects activated iNKT cells to the tumor site, promoting a local innate immune response, including direct lysis of targeted tumors by iNKT cells, release of large amounts of cytokines and transactivation of NK cells, altogether leading to prolonged antitumor effects. The gene discussed is CD1D; the disease is cancer.