Immunohistochemical analysis of the xenograft tissue confirmed that thetumors originating from LV-B7-H3 cells retained low expression levels of the B7-H3 protein,whereas the LV-NC group and the control group tumors showed strong B7-H3 staining.Furthermore, in the orthotopic transplantation pancreatic cancer model, we found thatdecreased B7-H3 expression reduced tumor metastasis. Here, CD276 is linked to familial pancreatic carcinoma.