MAPT and Alzheimer disease: New lines of investigation support the notion that tau malfunction, in addition to being independently capable of producing neurodegeneration even in the absence of Aβ deposits or other pathological events, could be a key mediator of neurodegeneration in response to other upstream events, including Aβ-induced neurotoxicity [20].It has been shown that Aβ can bind to tau and form a stable complex both in vitro and in AD brain [61].