TNFSF10 and chronic myelogenous leukemia, BCR-ABL1 positive: Recently, an animal study has demonstrated that Vγ9Vδ2 + T cells recognize trogocytosis and efficiently kills imatinib-sensitive and imatinib-resistant CML cell lines pretreated with zoledronate, and its cytotoxicity is largely dependent on the granule exocytosis- and, partially, TRAIL-mediated pathways, was TCR-mediated and required isoprenoid biosynthesis by zoledronate-treated CML cells.