Recently, a number of LAAs that are able to induce specific immune responses were identified in CML including telomerase, PR1, hyaluronan acid-mediated motility (RHAMM), CML-66, CML-28, CML-Ag165, NM23-H2, PPP2R5C, PR3, ELA2, PRAME and a novel epitope derived from the M-phase phosphoprotein 11 protein (MPP11)[34,36-42]. The gene discussed is PRAME; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.