Different alternative approaches for specific adoptive immunotherapy with CTLs targeted to different CML-associated LAAs were reported including CD8+ T cells from donors vaccinated against a single miHA expressed by leukemia cells, PRAME CTLs, donor derived b2a2-specific and b3a2-specific T cells, and Aur-A-specific CTLs[43,62-66]. This evidence concerns the gene XIAP and leukemia.