Recently, in a BCR-ABL1 transduction/transplantation mouse model for studying the DLI mechanisms in MHC-matched, miHA-mismatched allogeneic chimeras with CML-like leukemia, the GVL effect from DLI could be identified, and the GVL effect is directed against miHAs shared by normal and leukemic stem cells, which are predominantly mediated by CD8+ T cells with minor contributions from CD5-splenocytes including natural killer cells. The gene discussed is XIAP; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.