The RPM1 protein is known to beassociated with the host plasma membrane (Boyeset al. 1998), as is RPS2 (Mackey et al. 2003), where they recognizemodification in the Arabidopsis thaliananegative regulator RPM1interacting protein 4 (RIN4), target of Pseudomonas syringae type IIIbacterial effector proteins (Mackey etal. 2002), triggering the hypersensitive response (HR) or programmedcell death of infected cells, characterized by the appearance of small necrotic lesionsat infection sites. The gene discussed is RPS2; the disease is infection.