ZBTB10, which was an important target of miR-27a, suppressed the expression of vascular endothelial growth factor (VEGF), VEGF receptor 1 (VEGFR1), VEGFR2 and survivin which were responsible for angiogenesis and metastasis of cancer [24], [25].Suppression of miR-27a and induced expression of the miR-27a-regulated gene ZBTB10 mediated inhibition of tumor growth in breast cancer [18] in vitro and in vivo. The gene discussed is VEGFA; the disease is cancer.