B3GAT1 and infection: Such putative heterozygous genotype would preclude normal differentiation of CD56bright cells to CD56dim cells and in the acquisition of a CD62Llow/−CD16+CD57+CD158+ phenotype by CD56dim cells but would allow a sufficient number of NK cells to mature adequately and respond to activation stimuli, which in turn would provide a sufficient degree of NK cell activity to protect the patient from suffering major infections, in particular viral infections that are characteristic in patients with absolute or severe functional defects in NK cells [9].