MTDH and breast cancer: MTDH over-expression has been detected in esophageal squamous cell carcinoma [15], gastric cancer [16], renal cancer [17], prostate cancer [18], non-small cell lung cancer [19], hepatocellular carcinoma [20], breast cancer [21]–[22], and neuroblastoma [23], compared to normal cells and the matched non-neoplastic regions [24].