MLH1 and colorectal carcinoma: Recently, we demonstrated that certain SNPs in the mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (MLH1) gene region are associated with MLH1 promoter CpG island methylation, loss of MLH1 protein expression, and tumour microsatellite instability (MSI) phenotype in CRC patients [8].