In agreement with findings in cancer cells of other tumor types [16]–[17], [29]–[34], we observed that SM-164 not only improved APO2L/TRAIL-activity in sensitive BEL-7402 cell line, but also converted APO2L/TRAIL-resistant SMMC-7721 and HepG2 cell lines to become sensitive. This evidence concerns the gene TNFSF10 and neoplasm.