The reduction in the activity of the Akt pathway, as reported for several muscle atrophy models, causes a decrease in the cytosolic pFOXO and an increase in the nuclear FOXO protein that allows the up-regulation of atrogin-1/MAFbx and MuRF-1 and an increase in muscle atrophy [14]. The gene discussed is FBXO32; the disease is muscle atrophy.