Recently, we showed that dietary heme changed the surface to crypt signaling by downregulating feedback inhibitors of proliferation such as Wnt inhibitory factor 1 (Wif1), Interleukin-15 (IL-15), Indian Hedgehog (Ihh) and Bone morphogenetic protein 2 (Bmp2) in the surface epithelium [9].The resulting compensatory hyperproliferation and hyperplasia increases the risk of mutations in oncogenes and tumor suppressor genes and thereby increases the risk to develop colon cancer. Here, WIF1 is linked to malignant colon neoplasm.