TNFSF10 and cancer: LY30 produces high levels of ROS (reactive oxygen species), which may beparticularly harmful to cancer cells that have high metabolic rates and oxidative stress.Our recent studies found a synergistic anti-cancer effect by combining LY30 and TRAIL (Poh and Pervaiz, 2005; Poh et al., 2007; Shenoy et al., 2009).