The tumours generated from NCAM+ cells could be further propagated upon serial transplantation in NOD/SCID mice (currently generation 5), while histology and immunostaining of these tumours disclosed a blastema compartment that expressed NCAM, but also NCAM− differentiated epithelial-like structures and glumeruloid bodies, recapitulating the histology of both the parental WT and the p-WT Xn from which they were derived (Fig 2B). The gene discussed is NCAM1; the disease is neoplasm.