In addition, p-WT Xn overexpressed genes known to associate with poor prognosis WT: TOP2A, N-MYC and CRAB2P, correlating with a highly aggressive tumour phenotype (i.e blastema predominance; Green et al, 1994; Takahashi et al, 2002; Wittmann et al, 2008; Fig 1C). This evidence concerns the gene TOP2A and neoplasm.