Accordingly, taking into account that NCAM marks stem/progenitor cell compartments in various developing human organs (Schmelzer et al, 2006; Thomas et al, 2008; Tsokos et al, 1987) and that the corresponding paediatric solid tumours (e.g. hepatoblastoma, neuroblastoma and mesodermal tumours as rhabdomyosarcoma) recapitulate development, NCAM targeting might prove useful in a wide spectrum of developmental malignancies. This evidence concerns the gene NCAM1 and hepatoblastoma.