Imatinib (1uM) was shown to significantly increased the number of Annexin V positive cells, a hallmark of apoptosis, in the K562, JURLMK1 and Lama CML cell lines, but not in their imatinib-resistant counterparts (Figure 2B, C and D). The gene discussed is ANXA5; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.