GLRB and hereditary hyperekplexia: Based on our previous experience with GLRA1 and SLC6A5, we consider it likely that a number of recessive SNVs remain to be discovered in GLRB. Based on the discovery of four new GLRB variants associated with hyperekplexia in this year alone (Al-Owain et al., 2012; Lee et al., 2012, this study), we recommend that GLRB should have equal status alongside GLRA1 and SLC6A5 in the molecular genetic diagnosis of startle disease.