G6PD and anemia: The single 0.75 mg base/kg dose has generally been regarded as relatively safe[4,31] although in Vanuatu, where this dose of primaquine was introduced as a gametocytocide with the treatment of P falciparum malaria, over a period of two years seven cases of acute haemoglobinuria were observed with severe anaemia in G6PD deficient men and the policy was discontinued[44].