Compared to adults with normal pulmonary function, those with a restrictive impairment were more likely to have an elevated concentration of cotinine, hypertension, low levels of high-density lipoprotein cholesterol, an increased concentration of C-reactive protein >3 mg/l, an increased prevalence of diabetes, obesity, and abdominal obesity, an increased level of physical activity, and an elevated 10-year cardiovascular risk of >20%. The gene discussed is CRP; the disease is obesity disorder.