The RV144 trial that included priming with a recombinant canarypox vector, ALVAC-HIV vCP1521, followed by booster with the HIV-1 envelope gp120 protein, AIDSVAX gp120 clades B and E, plus an alum adjuvant showed a modest level of efficacy in reducing HIV-1 infection rates in Thailand [9]. The gene discussed is ITIH4; the disease is HIV-1 infection.