LRRC10 and familial dilated cardiomyopathy: Taken together our data show that prenatal Lrrc10−/− hearts exhibit different global changes in gene expression compared to adult hearts (Fig 4 vs. Fig 5), suggesting that early transcriptional alterations of actin cytoskeletal components may be directly linked to the molecular function of LRRC10 while gene expression changes in adulthood are likely to be compensatory or associated with the progression of DCM.