Further, mutations in Cypher/Zasp [19], MLP [20], nexilin [21], myopalladin [22], ILK [23], and desmin [24] have been found in human DCM patients, suggesting a prominent role for dysfunction of Z-disc and costamere proteins in the pathogenesis of DCM. The gene discussed is PSMB7; the disease is familial dilated cardiomyopathy.