Enhanced phosphorylation of Akt at Ser 473 has been observed in other animal models of DCM, including cTnT K210 deletion mice [77] and tachypacing-induced DCM in dogs [78], [79], as well as in response to transverse aortic constriction in mice [59], [80]. The gene discussed is TNNT2; the disease is familial dilated cardiomyopathy.