TNF and type 1 diabetes mellitus: [62], [63]; we therefore further examined the effect of these cytokines on Myt3 expression. Exposure of islets to Il-1β, TNFα and IFNγ in vitro resulted in a significant reduction in Myt3 expression. Furthermore, in a mouse model of T1D, immune infiltration into the islet results in a concomitant reduction in Myt3 expression likely due to exposure of the islets to pro-inflammatory cytokine secretion from the infiltrating immune cells confirming the in vivo relevance of our cytokine results.