More genes related to synaptic function were dysregulated in the cerebral cortex of the 3xTg-AD mice, whereas more genes related to insulin signaling (Insr, Grb2, Pten) and glucose metabolism (Ogt, Slc2a3, Slc2a4, Pck2) were down-regulated in the cerebral cortex of the icv-STZ mice. This evidence concerns the gene INSR and Alzheimer disease.