An extensively studied and used animal model is the triple transgenic mouse model, the 3xTg-AD mouse, which was generated by co-injecting two independent transgenic constructs encoding the Swedish mutations of human APP (APPSwe) and tauP301L into single-cell embryos harvested from the mutant homozygous PS1M146V knock in mice [3]. The gene discussed is APP; the disease is Alzheimer disease.