The icv-STZ mice and the 3xTg-AD mice show many alterations as what are seen in AD, but we found decreased, rather than increased, expression of pro-apoptotic genes, such as Bid and Bax. Autophagy is also dysregulated and is believed to contribute to the formation of hallmark AD pathologies [19], but we did not observe any significant changes of autophagy-related gene expressions. This evidence concerns the gene BID and Alzheimer disease.