Based on previous studies demonstrating global lysine demethylation on p53 following interaction with JMJD3 in differentiating neural stem cells [27], our results suggest that lysine 372 modifications may represent one of many putative mechanisms resulting in p53 protein stabilization following interaction with JMJD3 resulting in differentiation and suppression of proliferation in glioblastoma stem cells. Here, KDM6B is linked to glioblastoma.