PNPLA2 and Hepatic steatosis: In addition, the hepatic gene expression data agreed with reports showing the upregulation of Pparγ in MR rats [7] and its target genes: Cd36 and Atgl. In fact, rosiglitazone, a Pparγ agonist, was reported to ameliorate hepatic steatosis and improve insulin sensitivity [16], [35]–[38].