First, the CF mice on HFD presented significantly decreased adiponectin and FGF21 plasma levels compared to the CF mice on LFD (3.51±0.75 ng/ml vs. 4.58±0.41 ng/ml and 47.99±11.39 pg/ml vs. 163.96±54.77 pg/ml, p<0.01 by Student’s unpaired t-test, respectively, Table 3 and Table S2) suggesting insulin resistance due to HFD. Here, INS is linked to cystic fibrosis.