While fasting plasma insulin levels in CF mice fed LFD were similar to those in CF mice on HFD (Fig. 2B and Fig. S2B), the HOMA indexes for the CF mice fed LFD were significantly lower compared to the CF mice on HFD (8.67±3.29 vs. 14.93±9.78, p<0.001 by 2-way ANOVA; Fig. 2C and Fig. S2C). This evidence concerns the gene INS and cystic fibrosis.