SYT1 and rheumatoid arthritis: A difference in subclass of Syt-1 targeting autoantibodies might be decisive in harmless versus harmful autoreactivity, as it is known that IgG can recruit pro-inflammatory or anti-inflammatory pathways, depending on their subclass or post-translational modifications [59], [60], as it was observed for example in rheumatoid arthritis, where a changed glycosylation pattern of IgG is associated with pathogenesis [61].