SYT1 and Lambert-Eaton myasthenic syndrome: As autoantibody target, Syt1 was previously described in Lambert-Eaton myasthenic syndrome, an immune-mediated paraneoplastic disease affecting neuromuscular junctions, where it was suggested that Syt1 specific autoantibodies might interfere with presynaptic mechanisms and thus impair neuromuscular function [40], [41], [42], [43], [44], [45].