Multivariate analysis showed that tumor size >7.5 cm (P = 0.001, hazard ratio [HR] = 3.528; 95% confidence interval [CI]: 1.717–7.246), tumor number >1 (P = 0.004, HR = 2.196; CI 1.285–3.752), the presence of vascular invasion (P = 0.002, HR = 2.740; CI 1.450–5.177), the pre-LT serum AFP level ≥1000 ng/ml (P = 0.010, HR = 2.083; CI: 1.192–3.641) and an AST level ≥120 IU/L (P = 0.044, HR = 2.061; CI:1.021–4.160) were all independent predictors of poor survival post-LT. Here, AFP is linked to neoplasm.