We propose the adaption of expanded selection criteria for HCC patients with HBV-associated cirrhosis pre-LT: solitary tumor ≤7.5 cm, ≤4 multifocal nodules with the largest lesion ≤5 cm and a total tumor diameter ≤10 cm or more nodules with the largest lesion ≤3 cm, and a pre-LT serum AFP level ≤1000 ng/ml and a AST level <120 IU/L without vascular invasion of the major portal vein branches or lymph node metastasis. This evidence concerns the gene AFP and Cirrhosis.