MYC and leukemia: The dose of 10058-F4 used in our studies (25–50 uM) was chosen based on previously published experiments; functional studies in leukemia cell lines used 100 μM to inhibit c-MYC, and 60 μM of 10058-F4 was used to demonstrate that c-MYC inhibition increased levels of let-7a, let-7b, and miR-98 expression, mimicking the effects of siRNA knock down of c-MYC [37]–[39].