MYC and acute leukemia: In addition, a small molecule inhibitor of c-MYC, 10058-F4, which disrupts the interaction between c-MYC and its heterodimeric partner, MAX, thus preventing the complex from binding to a canonical E-Box DNA binding site, up-regulated miR-23a and miR-27a expression in 3 of 4 acute leukemia cell lines tested.