14-3-3 proteins are dysregulated in cancers [18] and can act as either tumor suppressors (14-3-3σ) or oncogenes (14-3-3β, ζ, γ, or θ) by binding and sequestering phosphorylated pro-apoptotic proteins such as BAX, BAD, ASK1, Foxo1 or Foxo3a [18]. The gene discussed is FOXO3; the disease is neoplasm.