ARRDC3 and neoplasm: [51] This is consistent with evidence that aArrs TXNIP and ARRDC3 are tumor suppressors, and that bArrs ARRB1/2 have predominantly oncogenic profiles. [25], [35], [52], [53] Our data mining observations are also consistent with opposite roles of aArrs TXNIP and ARRDC3 (pro obesogenic or diabeticogenic) compared to bArrs ARRB1 and 2 (anti). [23], [45], [54], [55] Taken together, these findings suggest that aArrs/bArrs function coordinately in the regulation of metabolism and cell growth.