Similar to the findings of comparative microarray analyses of MCF10A and MCF10.DCIS trancriptomes [70], we found up regulation of ABTB2, CX3CL1, DHRS9, GRHL2, HNMT, KRT6B, KRT7, LCN2, MYEOV, PLEKHF1, SEMA4A, and TNFRSF12A; down regulation of APOE, C1R, COL4A6, D4S234E, KRT14, and PCDH7; and differential expression of several members of various gene families like ALDH, CAPN, CCDC, CHST, ITGB, SLC and TMEM. This evidence concerns the gene COL4A6 and ductal breast carcinoma in situ.