Similar to the findings of comparative microarray analyses of MCF10A and MCF10.DCIS trancriptomes [70], we found up regulation of ABTB2, CX3CL1, DHRS9, GRHL2, HNMT, KRT6B, KRT7, LCN2, MYEOV, PLEKHF1, SEMA4A, and TNFRSF12A; down regulation of APOE, C1R, COL4A6, D4S234E, KRT14, and PCDH7; and differential expression of several members of various gene families like ALDH, CAPN, CCDC, CHST, ITGB, SLC and TMEM. The gene discussed is C1R; the disease is ductal breast carcinoma in situ.