Furthermore, in vitro studies suggest that the direct action of GLP-1 on hepatic steatosis is mediated by activation of key metabolic signalling pathways, including the AMP-activated protein kinase (AMPK) pathway and the insulin signalling pathway [8], [10], [11], which would be associated with increased hepatic fatty acid oxidation and hence improved insulin sensitivity. This evidence concerns the gene INS and Hepatic steatosis.