The interphase in situ hybridization technique is becoming a routinely available standard molecular assessment requested to reference Pathology Labs, due i.e. to the value of the Her-2 gene in breast, gastric cancers, 1p/19q in oligodendrogliomas or EGFR and ALK genes in lung adenocarcinoma [11], [12], [13], [14], [15]. The gene discussed is ALK; the disease is lung adenocarcinoma.