However, we note that the 3rd most significant differentially methylated CpG site (p = 8.03×10−05) was closest to Glutathione-S-Transferase (GSTP1) whose expression is increased by prolonged hypoxia [59] and whose loss of expression correlates with methylation in prostate cancer [60]. The gene discussed is GSTP1; the disease is Familial prostate cancer.