ARHGEF12 and neoplasm: For ARHGEF12, the integration was found in the tumor-adjacent tissues in two pairs of available samples, and both integrations increased the expression of ARHGEF12 in the tumor-adjacent samples (7.4 and 1.8 fold respectively, tumor-adjacent to tumor ratios), which is statistically significant different from ARHGEF12 expression in 9 pairs of samples without ARHGEF12 integration (the average expression ratio of normal to tumor tissues was 1.1, T-test P = 0.04) (Figure S2C).