Considering that 7 genes (PTPRJ, CNTN6, IL12B, MYOM1, FNDC3B, LRFN2, FN1)) contain the IPR003961: Fibronectin, type III domain (Table S6), we speculate that fibronectin type III repeat or like fibronectin type III repeat fold domain might play a role in HCC. Here, LRFN2 is linked to hepatocellular carcinoma.