FN1 and cancer: In summary, this study highlights these novel findings: 1) higher number of HBV integration events were found in cancer adjacent tissues than in HCC tissues, suggesting a clonal expansion process during HCC development; 2) fibronectin and its associated genes including fibronectin type III-like fold domain containing genes are frequently targeted by HBV DNA integration, and 3) 14 novel recurrent HBV targeted genes were identified when combined our list with recently published HBV targeted gene lists [14]–[16], greatly expanding the recurrent HBV human genome integration gene list.