PIK3R1 and breast cancer: Finally, breast cancer anti-estrogen resistance 1 (BCAR1), (Best SNP p value = 6.61×10−5, distance from gene = 16.5 Kb) is another gene that deserves attention, as is connected to 10 insulin genes, according to our network: CRK, SRC, PTPN1, PTK2, CRKL, PIK3R1, GRB2, PTPRF, RHOA and PTPRA. Interestingly, a SNP in an intronic region 16 Kb upstream this gene was reported to be strongly associated with type 1 diabetes [63].