IQ motif containing GTPase activating protein 2 (IQGAP2), the second ranked gene according to MAGENTA analysis, contained an intronic low frequency SNP (rs6453220; MAF = 0.05), which was strongly associated with glycated haemoglobin according to MAGIC WGA-meta-analyses (Hb1Ac; p = 4.19×10−6), providing more evidence that variants in IQGAP2 may contribute to insulin resistance. The gene discussed is IQGAP2; the disease is Insulin resistance.