INS and diabetes mellitus: Besides several enriched categories related to translation, Reactome Regulation of Expression in Beta Cells (p = 3.5×10−87, Odds Ratio = 15.8), Reactome Insulin Synthesis and Secretion (p = 4.46×10−79, Odds ratio = 14.0), and Reactome Diabetes pathways (p = 1.39×10−35, Odds ratio = 5.5) were also highly enriched among our set of internode genes.