Interestingly, by using cell lines inducibly expressing single HCV replicase proteins in U-2 OS human osteosarcoma cells, Egger and co-workers observed analogous membrane alterations in NS3/4A- and NS4B-expressing cells that corresponded to smooth SMVs and compact clusters of vesicles, the latter called MW [18]. This evidence concerns the gene KRAS and osteosarcoma.