However, interestingly, the carcinoma numbers per mouse were significantly lower in A-C/EBP+ mice as compared with A-C/EBP- mice when they were fed Dox-containing diet for 10 weeks from 52 weeks post-1st NNK administration (group 1 vs. 2) as determined by histopathological analysis. This evidence concerns the gene CEBPA and carcinoma.