CEBPA and lung cancer: In this study, CCSP-rtTA;TetO-A-C/EBP mice were subjected to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung carcinogenesis bioassay [23] in the presence and absence of doxycycline, and the effect of A-C/EBP expression on the development and/or progression of lung cancer was examined.