Table 3 shows patients with DM for longer than 2 years were at higher risk of the cancer than patients with shorter DM history with an OR of 2.28 (95% CI 0.85-6.08) after controlling for sex, age, alcoholism, periodontal disease, esophagus ulcer, esophagus reflux, COX-2 inhibitors and other NSAIDs. The gene discussed is PTGS2; the disease is periodontal disorder.