Specific inhibition of these pathways can have a favorable impact on DC phenotype and the capacity for meaningful immunologically mediated anticancer response, for example a murine tumor model was induced to be immunologically rejected by use of VEGF depleting antibody (Gabrilovich et al., 1999); a clinical trial using sequential bevacizumab (humanized anti-VEGF antibody, Roche USA, Indianapolis, IN) and then low dose subcutaneous IL-2 did not demonstrate a significant clinical impact nor impact on DC phenotype for VEGF depletion (Finkelstein et al., 2010). Here, VEGFA is linked to neoplasm.