High mobility group box 1 (HMGB1) is a protein which is released from some dying cells, including tumor cells killed by anthracyclines (Fucikova et al., 2011), and in a hyperthermia and radiation combination model (Schildkopf et al., 2010 ), and with radiation and chemotherapy combination treatments for colorectal cancer cell lines, particularly with the combination (Frey et al., 2012). Here, HMGB1 is linked to colorectal cancer.