Similarly, reducing VDAC1 expression by siRNA efficiently prevented cisplatin-induced apoptosis and Bax activation in NSCLC (Tajeddine et al., 2008), attenuated endostatin-induced apoptosis (Yuan et al., 2008) and inhibited selenite-induced PTP opening (Tomasello et al., 2009). This evidence concerns the gene COL18A1 and non-small cell lung carcinoma.