Similarly, reducing VDAC1 expression by siRNA efficiently prevented cisplatin-induced apoptosis and Bax activation in NSCLC (Tajeddine et al., 2008), attenuated endostatin-induced apoptosis (Yuan et al., 2008) and inhibited selenite-induced PTP opening (Tomasello et al., 2009). The gene discussed is VDAC1; the disease is non-small cell lung carcinoma.