The mitochondria bound-isoforms, HK-I and HK-II, were found to be over-expressed in many cancers, including colon, prostate, lymphoma, glioma, gastric adenomas, carcinomas, and breast cancers (Gottlob et al., 2001; Bryson et al., 2002; Mathupala et al., 2010). The gene discussed is HK1; the disease is cancer.