VDAC1 over-expression was observed in a cisplatin-sensitive cervix squamous cell carcinoma cell line (A431) when exposed to cisplatin, while in a cisplatin-resistant cell line (A431/Pt), the treatment resulted in down-regulation of VDAC1 (Castagna et al., 2004). The gene discussed is VDAC1; the disease is cervical squamous cell carcinoma.