Two lines were primarily generated, one with low (tg1222) and one with high LT expression levels (tg1223), to examine the impact of the LTβR signalaing pathway on chronic hepatitis and hepatitis-induced HCC (67) At the age of 4 to 6 months, the livers of tg1223 mice showed signs of massive portal and lobular inflammation whereas tg1222 livers showed only mild portal inflammation (67). This evidence concerns the gene LTA and hepatocellular carcinoma.