In addition, Ghelani and co-workers observed that the deregulation of the expression of specific miRNAs could be associated with several types of neurodegenerative disorders, the downregulation of miR-9 and miR-107 were associated with Alzheimer's disease (AD), due to their impact on the modulation of insulin resistance and innate immunity pathways (Shioya et al., 2010; Ghelani et al., 2012; Saito and Saito, 2012). Here, INS is linked to Alzheimer disease.