The co-presence of distinct subsets within the intrahepatic memory CD8 T cell pool in mice protected against malaria is consistent with an earlier view that virally induced memory CD8 T cells are organized into subsets on the basis of distinct functional activities and the maturation/activation status (Sallusto et al., 1999; Kaech et al., 2002; Wherry et al., 2003). Here, CD8A is linked to malaria.