Cardiomyocyte (CMs) isolated from wild mice undergoing sepsis produced high levels of IL-6, TNF-α, IL-1β, MIP-1α, MIP-2, MCP-1, and KC, while CMs from C5L2-deficient mice secreted significant low level of the inflammatory mediators (Atefi et al., 2011). This evidence concerns the gene C5AR2 and Sepsis.