Furthermore, a recent study showed that polymicrobial sepsis greatly induced generation of inflammatory mediators in hearts, and CMs isolated from septic rodents spontaneously secreted cytokines and chemokines (IL-6, TNF-α, IL-1β, MIP-1α, MIP-2, MCP-1, KC, and IL-10) in a time-dependent manner (Atefi et al., 2011). Here, CALCA is linked to Sepsis.