In vitro, C5aR expression was elevated in γδT cells treated with C5a (Han et al., 2011), and incubation of γδT cells with C5a stimulated IL-17 expression (Han et al., 2011), implying the involvement of C5a/C5aR signaling in the release of inflammatory mediators from γδT cells during sepsis. The gene discussed is IL17A; the disease is Sepsis.