Clinical questionnaires such the Asthma Control Questionnaire (Juniper et al., 1999b) and the Asthma Quality of Life Questionnaires (Juniper et al., 1999a) that have been validated to identify clinical improvement after weeks of ICS therapy (Juniper et al., 1994), show significant clinical improvements in AHR to mannitol following the introduction of ICS (Baraket et al., 2012; Turton et al., 2012). The gene discussed is AHR; the disease is asthma.